Water → 2,2-Dimethyl-3-phenylpropanoic acid

HRID 274821ノート

反応式

HRID 274821 の反応式
[CH3:1][C:2]([CH3:15])([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[K+].O>CO>[CH3:1][C:2]([CH3:15])([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4]

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 4684633Ethyl 2,2-dimethyl-3-phenylpropanoate

生成物 1

HCID 218802,2-Dimethyl-3-phenylpropanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1 g (20 mmol) of ethyl 2,2-dimethyl-3-phenylpropionate (stage 1) and 3.5 g (61 mmol) of potassium hydroxide in 15 ml of methanol was heated under reflux for 2 hours. Thereafter, 50 ml of water were added and the mixture was extracted twice with ether. The aqueous phase was acidified with concentrated hydrochloric acid and extracted again with ether, the organic phase was dried over magnesium sulfate and the solvent was striped off in vacuo.

後処理

  1. temperatureunder reflux for 2 hours
  2. extractionthe mixture was extracted twice with ether
  3. extractionextracted again with ether
  4. dry with materialthe organic phase was dried over magnesium sulfate

出典と根拠

ORDレコード
ord-efca2393aca843ff81caf973a753a5b9
出典データセット
uspto-grants-1995_02
特許番号
USRE034865

反応ノート

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