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Sodium hydride → HCID 21478104、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 3-amino-4,4,4-trifluoro-2-butenoate | HCID 136209 | — |
| 反応物 | HCID 21478106 | HCID 21478106 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 21478104 | HCID 21478104 | 55.8% |
反応手順
By the method of Example 1, Step G, 19.67 grams (0.080 mole) of 2,3-dichloro-5-nitrophenylmethyl isocyanate, 2.102 grams (0.088 mole) of sodium hydride, and 14.59 grams (0.080 mole) of ethyl 3-amino-4,4,4-trifluoro-2-butenoate were reacted in 80 mL of N,N-dimethylformamide, yielding 17.14 grams of 3-(2,3-dichloro-5-nitrophenylmethyl)-6-trifluoromethyluracil as a brown solid. The NMR spectrum was consistent with the proposed structure. This reaction was repeated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05391541 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-243f72489f334deba3a8e63976ee3ebc |
| 出典メモ | uspto-grants-1995_02 |