Phosphorus oxychloride → 9-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine

HRID 274868ノート

反応式

HRID 274868 の反応式
[CH2:1]([C:13]1[CH:26]=[C:25]2[C:16]([N:17]=[C:18]3[C:23](=[C:24]2O)[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].O=P(Cl)(Cl)[Cl:30]>>[Cl:30][C:24]1[C:25]2[C:16]([N:17]=[C:18]3[C:23]=1[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=[C:13]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:26]=2

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178442815HCID 178442815、化合物

生成物 1

HCID 200889899-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine

実験手順

Three grams of 7-dodecyl-9-hydroxy-1,2,3,4-tetrahydroacridine was refluxed for 30 minutes in 30 mL of POCl3. At the end of this time the POCl3 was evaporated and the residue distributed between aqueous NH3 and ethyl ether. The organic phase was dried and evaporated to give 9-chloro-7-dodecyl-1,2,3,4-tetrahydroacridine (3.0 g) as a solid. A small sample was recrystallized from methanol to give fine needles, mp 36°-38°.

後処理

  1. customAt the end of this time the POCl3 was evaporated
  2. customThe organic phase was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-98a53e2b3cc04ca08e646f733569aa39
出典データセット
uspto-grants-1995_02
特許番号
US05391553

反応ノート

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