Water → HCID 20088899、化合物

HRID 274877

反応式

HRID 274877 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:13]([C:21]([O-:23])=[O:22])=[N:14][C:15]([N:18]([CH3:20])[CH3:19])=[CH:16][CH:17]=2)[N:4]=1.[K+].[CH2:25]([O:27][C:28]([O:30][CH:31](Cl)[CH3:32])=[O:29])[CH3:26].O>CN(C)C=O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][C:12]2[C:13]([C:21]([O:23][CH:25]([O:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH3:26])=[O:22])=[N:14][C:15]([N:18]([CH3:19])[CH3:20])=[CH:16][CH:17]=2)[N:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 162095Carbonic acid, 1-chloroethyl ethyl esterHCID 23710069HCID 23710069、化合物

生成物 1

HCID 20088899HCID 20088899、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2.0 g (5.6 mmol) of potassium 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate and 0.8 g (5.7 mmol) of 1-(ethoxycarbonyloxy) ethylchloride were suspended in 5 ml of dimethylformamide, and were stirred at room temperature for 6 hours. The reaction mixture was poured into water, and was extracted with ethyl acetate twice. The organic layer was then washed with water and dried, and the solvent was distilled off to obtain a viscous product which was then column-purified to obtain an aimed compound.

後処理

  1. extractionwas extracted with ethyl acetate twice
  2. washThe organic layer was then washed with water
  3. customdried
  4. distillationthe solvent was distilled off
  5. customto obtain a viscous product which
  6. customwas then column-purified

出典と根拠

ORDレコード
ord-4e6006c90f2948af92b946712e3570a3
出典データセット
uspto-grants-1995_02
特許番号
US05391537

関連ノート

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