Water → Potassium 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate

HRID 274878ノート

反応式

HRID 274878 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:13]([C:21]([O:23]C)=[O:22])=[N:14][C:15]([N:18]([CH3:20])[CH3:19])=[CH:16][CH:17]=2)[N:4]=1.[OH-].[K+:26].O>CO>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][C:12]2[C:13]([C:21]([O-:23])=[O:22])=[N:14][C:15]([N:18]([CH3:19])[CH3:20])=[CH:16][CH:17]=2)[N:6]=1.[K+:26]

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 15767146Methyl 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate

生成物 1

HCID 23710069Potassium 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

9.2 g (27.5 mmol) of methyl 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate was dissolved in 30 ml of methanol, and 1.55 g (27.5 mmol) of 10% potassium hydroxide was added thereto. Furthermore, 20 ml of water was added thereto, and the resultant mixture was stirred at room temperature. The reaction liquor was concentrated under reduced pressure, and acetone was added thereto to precipitate a crystal. The crystal thus obtained was separated by filtration and was washed with hexane to obtain an aimed compound.

後処理

  1. concentrationThe reaction liquor was concentrated under reduced pressure, and acetone
  2. additionwas added
  3. customto precipitate a crystal
  4. customThe crystal thus obtained
  5. customwas separated by filtration
  6. washwas washed with hexane

出典と根拠

ORDレコード
ord-d93e6d9e801d4e598a53a7bbcc25c9fb
出典データセット
uspto-grants-1995_02
特許番号
US05391537

反応ノート

読み込み中…