Diethyl Ether → 1-(Phenylcarbamoyl)-2-pyrazoline

関与物質

反応手順

2.76 g (0,008 mol) of 3-(4'-chlorophenyl)-4-(4"-methyl-3"-trifluoromethyl-Δ2" -1",2",4"-triazolin-5"-on-1"-yl)-4,5-dihydropyrazole are dissolved in 20 ml of acetonitrile (anhydrous) at 60° C. until a clear solution has formed, this solution is treated with 1.7 g of 4-trifluoromethoxy-phenyl isocyanate, and 2drops of triethylamine are added. The mixture is subsequently allowed to stand for 2 hours at room temperature. The solvent is subsequently stripped off in vacuo, the residue is treated with 20 ml of diethyl ether and, after 2 hours, the precipitate which has formed is filtered off with suction. 2.0 g (45.6% of theory) of N-(4-trifluormethoxy)-3-(4'-chlorophenyl)-4-(4"-methyl-3"-trifluoromethyl-Δ2" -1",2",4,"-triazolin-5"-on-1"-yl)-4,5-dihydro-1-pyrazole-carboxanilide having a melting point of 241° C. are obtained.

情報源と証拠