Water → 4-Benzo[1,3]dioxol-5-yl-4-hydroxycyclohexanone

HRID 274893

反応式

HRID 274893 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([OH:20])[CH2:19][CH2:18][C:13]4(OCC[O:14]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1.O>CC(C)=O.Cl>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([OH:20])[CH2:11][CH2:12][C:13](=[O:14])[CH2:18][CH2:19]3)=[CH:9][C:4]=2[O:3][CH2:2]1

参加物

5

反応物 2

HCID 962WaterHCID 109128408-(Benzo[d][1,3]dioxol-5-yl)-1,4-dioxaspiro[4.5]decan-8-ol

生成物 1

HCID 151996894-Benzo[1,3]dioxol-5-yl-4-hydroxycyclohexanone収率 95%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 8-(1,3-benzodioxol-5yl)-1,4-dioxaspiro[4.5]decan-8-ol (IIIb; 5 g, 18 mmole) in 75 ml acetone, 1 ml 12 N HCl, and 50 ml water, was stirred for 2 hr. After dilution with an additional 50 ml water the solid was collected to give the product (4.0 g, 95%, mp: 166°-168° C.).

後処理

  1. customAfter dilution with an additional 50 ml water the solid was collected

出典と根拠

ORDレコード
ord-9b797b45feae49c982223b3f7a5feaff
出典データセット
uspto-grants-1995_02
特許番号
US05391570

関連ノート

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