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Hydrochloric Acid → 4-(1,3-Benzodioxol-5-yl)-4-methoxycyclohexanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 8-(Benzo[d][1,3]dioxol-5-yl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 10912840 | — |
| 生成物 | 4-(1,3-Benzodioxol-5-yl)-4-methoxycyclohexanone | HCID 22924043 | 70% |
反応手順
A solution of 8-(1,3-Benzodioxol-5-yl)-1,4-dioxa-spiro[4.5]decan8-ol (5.0 g, 1.8 mmole) in 100 mL methanol with 1 mL conc. hydrochloric acid was stirred for 22 hr and the solution concentrated in vacuo. The residue was purified by chromatography on silica eluting with ethyl acetate-hexane (1:19) to give the product (70%, mp: 84°-85 ° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05391570 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-0fc48e1455e3459ebe6c2592c514e614 |
| 出典メモ | uspto-grants-1995_02 |