1,4-Dioxaspiro[4.5]decan-8-one → 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

反応式

[CH2:1]1[O:11][C:4]2([CH2:9][CH2:8][C:7](=[O:10])[CH2:6][CH2:5]2)[O:3][CH2:2]1.[F:12][C:13]1[CH:14]=[C:15]([Mg]Br)[CH:16]=[CH:17][C:18]=1[F:19]>>[F:12][C:13]1[CH:14]=[C:15]([C:7]2([OH:10])[CH2:6][CH2:5][C:4]3([O:3][CH2:2][CH2:1][O:11]3)[CH2:9][CH2:8]2)[CH:16]=[CH:17][C:18]=1[F:19]

参加物

反応物 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-one

HCID 178505835HCID 178505835、化合物

生成物 1

HCID 221221048-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol収率 42%

実験手順

This compound was prepared from 1,4-cyclohexanedione monoethylene ketal (15.6 g, 100 mmole) and 3,4-difluorophenyl magnesium bromide (100 mmole) in the usual manner. The crude product was crystallized from isopropyl ether to give the product (42%, mp: 118°-120° C.).

後処理

customThe crude product was crystallized from isopropyl ether

出典と根拠

ORDレコード: ord-4f7081b16600494da2768c7c3173e73b
出典データセット: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05391570

反応ノート

読み込み中…