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Formaldehyde → (1,4-dimethyl-1H-imidazol-2-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | 1,4-Dimethylimidazole | HCID 138733 | — |
| 反応物 | (5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-3-yl)methanol | HCID 12923422 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | (1,4-dimethyl-1H-imidazol-2-yl)methanol | HCID 12923402 | — |
反応手順
The reaction of 1,4-dimethylimidazole (5.65 g.) with n-butyl lithium followed by treatment with formaldehyde (according to the method described for the preparation of 3-hydroxymethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in Example 243) gave 1,4-dimethyl-2-hydroxymethylimidazole (2.71 g.), m.p. 125°-126° (ethyl acetate-petroleum ether).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221802 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-68e91c5cca904f2c8b0a3bb8606e145b |
| 出典メモ | uspto-grants-1980_09 |