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HRID 274988作成日：2026年10月27日
2-Cyanoethyl tetraisopropylphosphorodiamidite → Diisopropylamino-5-(carbomethoxy)pentyloxy-2-cyanoethoxy phosphine
https://huagongshe.com/reaction/274988
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Cyanoethyl tetraisopropylphosphorodiamidite | HCID 128153 | — |
| 反応物 | Hexanoic acid, 6-hydroxy-, methyl ester | HCID 3083855 | — |
| 反応物 | HCID 178458033 | HCID 178458033 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Diisopropylamino-5-(carbomethoxy)pentyloxy-2-cyanoethoxy phosphine | HCID 20089729 | — |
反応手順
To a solution of 0.786 g (5.37 mmole) of methyl-6-hydroxyhexanoate and 0.48 g (2.8 mmole) of diisopropylammonium tetrazolide in 25 ml of dichloromethane were added dropwise 1.62 g (5.37 mmole) of bis(diisopropyl amino)-2-cyanoethyoxyphosphine (Aldrich). The resulting solution was stirred at 25° C. for 2 hours and extracted with phosphate buffer at pH 7. Drying over magnesium sulfate and fast chromatography on silica gel (40% ethylacetate-hexanes, trace triethylamine) yielded the diisopropylamino-5-(carbomethoxy)pentyloxy-2-cyanoethoxy phosphine linking group as a colorless oil (1.30 g: 70%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05391723 |
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| 出典データセット | uspto-grants-1995_02 |
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| ORD ID | ord-2389888995ce4186becda88fbe432b3f |
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| 出典メモ | uspto-grants-1995_02 |
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