Dimethylformamide → N-dimethylaminomethyleneguanine

反応式

[NH:1]1[C:10](=[O:11])[C:9]2[NH:8][CH:7]=[N:6][C:5]=2[N:4]=[C:2]1[NH2:3].[CH3:12][N:13]([CH3:16])[CH:14]=O.P(Cl)(Cl)(Cl)=O.C(=O)([O-])O.[Na+]>>[CH3:12][N:13]([CH:16]=[N:3][C:2]1[NH:1][C:10](=[O:11])[C:9]2[NH:8][CH:7]=[N:6][C:5]=2[N:4]=1)[CH3:14]

参加物

反応物 4

HCID 6228Dimethylformamide

HCID 24813Phosphorus oxychloride

HCID 516892Sodium Bicarbonate

HCID 135398634Guanine

生成物 1

HCID 136087653N-dimethylaminomethyleneguanine収率 71%

反応条件

温度: 30 °C

実験手順

15.1 g (0.1 mol) of guanine (manufactured by Sumika Fine Chemicals Co., Ltd.) was added to 175.4 g (2.4 mol) of N,N-dimethylformamide, and then 23.0 g (0.15 mol) of phosphorus oxychloride was added drop by drop, followed by stirring at 30° C. for 1 hour. The reaction mixture was added to 500 ml of ice water, and then neutralized with 75.6 g (0.9 mol) of sodium hydrogen carbonate. The precipitating crystal was collected by filtration and washed with 50 ml of water to yield 14.6 g (0.07 mol) of a white crystal of N-dimethylaminomethyleneguanine (yield 71%). Its properties are as follows:

後処理

filtrationThe precipitating crystal was collected by filtration
washwashed with 50 ml of water

出典と根拠

ORDレコード: ord-3f223a7b2deb4c0b8c397e8ed08f9142
出典データセット: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05391733

反応ノート

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