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Sodium → 2-(3-Phthalimidopropylthio)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Water ethanol | HCID 19096565 | — |
| 反応物 | Bromopropylphthalimide | HCID 21958088 | — |
| 反応物 | HCID 178418793 | HCID 178418793 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(3-Phthalimidopropylthio)pyrimidine | HCID 3462547 | — |
反応手順
A mixture of 2-mercaptopyrimidine (5.6 g.) and 3-bromopropylphthalimide (13.4 g.) in ethanol (100 ml.) containing sodium (1.15 g.) was heated under reflux for 20 hours to give 2-(3-phthalimidopropylthio)pyrimidine, m.p. 81.5°-82.5° (from ethanol-water). Reaction of the phthalimido compound (3.7 g.) and hydrazine (1.86 g.) followed by reaction of the product directly with N-cyano-N',S-dimethylisothiourea by the procedure of Example 3(a) gives N-cyano-N'-methyl-N"-[3-(2-pyrimidylthio)propyl]guanidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221802 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-a83a4403f04949f0814eee6f308b82ad |
| 出典メモ | uspto-grants-1980_09 |