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Ethylene Glycol → 2-(2-Hydroxyethoxymethyl)pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | Pyrazine, 2-(chloromethyl)- | HCID 170169 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 生成物 | 2-(2-Hydroxyethoxymethyl)pyrazine | HCID 20567544 | — |
反応手順
2-Chloromethylpyrazine is reacted with the sodium salt of ethylene glycol to give 2-(2-hydroxyethoxymethyl)pyrazine which is treated with thionyl chloride to give 2-(2-chloroethoxymethyl)pyrazine. Using this intermediate in place of 4-(3-chloropropoxy(methylimidazole in the procedure of Example 22 gives the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221802 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-738a1d3057c54f41b9c4d43bb5ae35b6 |
| 出典メモ | uspto-grants-1980_09 |