化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl diazoacetate → 3-Benzyl-2-oxo-3-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl diazoacetate | HCID 12192 | — |
| 反応物 | 1-Benzyl-5,6-dihydropyridin-2(1H)-one | HCID 11116784 | — |
| 触媒 | Molybdenum carbonyl (Mo(CO)6) | HCID 98885 | — |
| 生成物 | 3-Benzyl-2-oxo-3-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester | HCID 54284495 | — |
反応手順
These compounds can be prepared from 1-benzyl-5,6-dihydro-2(1H)-pyridinone by reaction with ethyl diazoacetate with molybdenum hexacarbonyl catalyst to provide 3-benzyl-2-oxo-3-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester, which can be reduced with lithium aluminum hydride to provide 3-benzyl-7-hydroxymethyl-3-azabicyclo[4.1.0]heptane. Utilization of the methods in Section VIII then yields the desired 7-R7 -substituent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05391763 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-5fa1f061ec9b4aa79a03d4b212a8022f |
| 出典メモ | uspto-grants-1995_02 |