化工社化工社 化学情報印刷レポート · 研究参考用
4-(Trifluoromethyl)phenylhydrazine → 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)phenylhydrazine | HCID 136200 | — |
| 反応物 | 2-(3-Trifluoromethylbenzoyl)nicotinic acid | HCID 20078895 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone | HCID 178519560 | 80.7% |
反応手順
2-(3-Trifluoromethylbenzoyl)nicotinic acid (0.5 g), 4-trifluoromethylphenylhydrazine (0.3 g) and para-toluene sulphonic acid (0.001 g) were stirred in methanol at room temperature for 22 hours. Solvent was evaporated. The residue was triturated in cold toluene then dried to yield the title compound as a beige solid (0.62 g), m.p. 127°-129° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05393730 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-0f21748979904a6cb9e4027cefd1fe85 |
| 出典メモ | uspto-grants-1995_02 |