関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Oxygen difluoride | HCID 24547 | — |
| 反応物 | Acetyl hypofluorite | HCID 127602 | — |
| 反応物 | alpha-D-Glucopyranose, 2-deoxy-2-(fluoro-18F)- | HCID 450503 | — |
| 反応物 | N-Formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester | HCID 11828229 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Trichlorofluoromethane | HCID 6389 | — |
| 生成物 | Oxygen difluoride | HCID 24547 | — |
| 生成物 | Acetyl hypofluorite | HCID 127602 | — |
| 生成物 | N-Formyl-3,4-di-t-butoxycarbonyloxy-6-fluoro-L-phenylalanine ethyl ester | HCID 15345888 | — |
反応手順
The electrophilic fluorinating agent, CH3COOF (prepared from 200 μmol) of F2 in 1% He, (Bida, G. T., Satyamurthy, N. and Barrio, J. R. (1984) The synthesis of 2-[18F]fluoro-2-deoxy-D-glucose using glycals: A reexamination. J. Nucl. Med. 25, 1327) F2 (1% in He, 200 μmol) or OF2 (1% in He, 200 μmol), was bubbled into a solution of trimethyltin derivative 6 (0.123 g, 200 μmol) in Freon-11 (CFCl3) (20 mL) at room temperature over a period of 30 min. The reaction mixture was diluted with methylene chloride (25 mL) and the organic phase was washed with 1M Na2S2O5 (2×20 mL), water (2×20 mL) and dried (MgSO4). Evaporation of solvents gave a yellow syrup which was chromatographed (silica gel, diethyl ether) to yield a colorless viscous oil 9 (41 mg, 43% in the case of CH3COOF), (65 mg, 69% for F2), (62 mg, 66% for OF2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05393908 |
|---|
| 出典データセット | uspto-grants-1995_02 |
|---|
| ORD ID | ord-7a49c58bbbd24d8bb548a600f68ed707 |
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| 出典メモ | uspto-grants-1995_02 |
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