HCID 67571180、化合物 → HCID 54148932、化合物

HRID 275544ノート

反応式

HRID 275544 の反応式
[C:1]([N:20]1[C:24](/[CH:25]=[CH:26]/[CH2:27][OH:28])=[N:23][CH:22]=[N:21]1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[C].[Pd]>[C:1]([N:20]1[C:24]([CH2:25][CH2:26][CH2:27][OH:28])=[N:23][CH:22]=[N:21]1)([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 1

HCID 67571180HCID 67571180、化合物

生成物 1

HCID 54148932HCID 54148932、化合物収率 74.3%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A stirred solution of E-3(1-trityl-1,2,4-triazol-5-yl)prop-2-en-1-ol (9.5 g, prepared as described in Example 9) in dichloromethane (100 ml) was hydrogenated over 5% palladium-carbon (50 mg) at room temperature and pressure for four hours. The mixture was filtered through Hyflo Super-Cel, evaporated under reduced pressure and chromatographed, using ethyl acetate-hexane (4:1), then ethyl acetate, as eluants, to give 3(1-trityl-1,2,4-triazol-5-yl)propanol (7.1 g, m.p. 150°-152° C.). NMR (CDCl3): δ1.4(2H,m), 2.2(2H,t), 3.45(2H,t), 7.1-7.3(15H,m), 7.9(1H,s).

後処理

  1. filtrationThe mixture was filtered through Hyflo Super-Cel
  2. customevaporated under reduced pressure
  3. customchromatographed

出典と根拠

ORDレコード
ord-b5d13a163ef548ddbdb48087aa4281c7
出典データセット
uspto-grants-1995_02
特許番号
US05393732

反応ノート

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