Ethylenediamine → N-methyl-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea
反応式
BrCC1C=CSN=1.C(N)CN.[S:12]1[CH:16]=[CH:15][C:14]([CH2:17][NH:18][CH2:19][CH2:20][NH2:21])=[N:13]1.[CH3:22][N:23]=[C:24]=[S:25]>>[CH3:22][NH:23][C:24]([NH:21][CH2:20][CH2:19][NH:18][CH2:17][C:14]1[CH:15]=[CH:16][S:12][N:13]=1)=[S:25]参加物
5
実験手順
Reaction of 3-bromomethylisothiazole with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(3-isothiazolylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) and then chromatographing gives N-methyl-N'-[2-(3-isothiazolylmethylamino)ethyl]thiourea. This intermediate is reacted with lead cyanamide by the procedure of Example 3(b) to give N-cyano-N'-[2-(3-isothiazolylmethylamino)ethyl]-N"-methylguanidine. Hydrolysis of the last prepared compound by the procedure of Example 3(e) gives N-[2-(3-isothiazolylmethylamino)ethyl]-N'-methylguanidine dihydrochloride.
出典と根拠
- ORDレコード
- ord-e5beec7efc2a4fbdb0320f4dc6f2cbb5
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04221802
反応ノート
読み込み中…