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2-Naphthalenesulfonyl chloride → N-(2-naphthylsulfonyl)-glycine t-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Naphthalenesulfonyl chloride | HCID 7125 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Glycine tert-butyl ester hydrochloride | HCID 2725036 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(2-naphthylsulfonyl)-glycine t-butyl ester | HCID 19081114 | 87.3% |
反応手順
14.4 ml of triethylamine are added dropwise to 6.91 g of glycine t-butyl ester hydrochloride and 12.1 g of 2-naphthylsulfonyl chloride in 70 ml of methylene chloride. The reaction mixture is subsequently diluted with 200 ml of ether. The organic phase is washed with 1N hydrochloric acid and with water. After drying and evaporation the residue is suspended in ether and suction filtered. After drying the crystals there are obtained 11.57 g of N-(2-naphthylsulfonyl)-glycine t-butyl ester, Rf=0.49 (ether/hexane 2:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05393760 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-1b689844d4b745aaa6c1ca08ec6dcf3c |
| 出典メモ | uspto-grants-1995_02 |