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N-[(benzyloxy)carbonyl]-3-(imidazol-1-yl)-L-alanine → (S)-alpha-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(imidazol-1-yl)propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[(benzyloxy)carbonyl]-3-(imidazol-1-yl)-L-alanine | HCID 10859191 | — |
| 反応物 | (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol | HCID 14930738 | — |
| 生成物 | (S)-alpha-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(imidazol-1-yl)propionamide | HCID 53847799 | — |
反応手順
In an analogous manner to that described above, by the condensation of N-[(benzyloxy)carbonyl]-3-(imidazol-1-yl)-L-alanine and (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol followed by catalytic hydrogenation there was obtained (S)-α-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(imidazol-1-yl)propionamide, MS: 365 (M+H)+, as a colourless foam.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05393875 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-b0c472b56fac4fe298992e5ae710996e |
| 出典メモ | uspto-grants-1995_02 |