Imidazole → 2-(2-Iodoethyl)indane

HRID 275717

反応式

HRID 275717 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[CH2:10][CH2:11]O.N1C=CN=C1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[I-:37]>C1(C)C=CC=CC=1>[I:37][CH2:11][CH2:10][CH:2]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1]1

参加物

6

反応物 4

HCID 795ImidazoleHCID 11776TriphenylphosphineHCID 30165Iodide IonHCID 103520002-(2,3-dihydro-1H-inden-2-yl)ethanol

生成物 1

HCID 185458332-(2-Iodoethyl)indane収率 87.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
90 °C

実験手順

A mixture of 2-(indan-2-yl)ethanol (19.3 g), imidazole (12.1 g), triphenylphosphine (34.3 g), and toluene (250 ml) was heated to 90° C. To this mixture, iodide (33.2 g) was added, and the resulting mixture was stirred at 90° C. for 20 min. The mixture was allowed to cool to room temperature. filtered, and concentrated in vacuo. The residue was purified on silica gel eluted with ethyl acetate-heptane (1:4) to give an oil (28.4 g, 87%).

後処理

  1. temperatureto cool to room temperature
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo
  4. customThe residue was purified on silica gel
  5. washeluted with ethyl acetate-heptane (1:4)

出典と根拠

ORDレコード
ord-9d7eea3300c943ff991280db890d539d
出典データセット
uspto-grants-2002_03
特許番号
US06352988B2

関連ノート

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