2-Bromopropane → 2,3-Dimethyl-1-(2-propyl)oxybenzene

HRID 275725

反応式

HRID 275725 の反応式
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Br[CH:17]([CH3:19])[CH3:18]>CC(C)=O>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH:17]([CH3:19])[CH3:18]

参加物

5

反応物 3

HCID 63582-BromopropaneHCID 106872,3-DimethylphenolHCID 11430Potassium Carbonate

生成物 1

HCID 203083562,3-Dimethyl-1-(2-propyl)oxybenzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a stirred solution/suspension of 2,3-dimethylphenol (10 g) and potassium carbonate (6.8 g) in acetone (150 ml) at reflux was added 2-bromopropane (46 ml) drop-wise over 30 min. The solution was heated at reflux for 4 days. After cooling, the solvent was evaporated and the residue was dissolved in ether and water. The ether phase was separated and was worked up according to the general procedure. Column chromatography on silica gel (eluent:ethyl acetate/heptane 1:19) afforded pure 2,3-dimethyl-1-(2-propyl)oxybenzene (13.2 g) as a mobile, slightly brown oil which was used without further purification.

後処理

  1. temperatureat reflux
  2. temperatureThe solution was heated
  3. temperatureat reflux for 4 days
  4. temperatureAfter cooling
  5. customthe solvent was evaporated
  6. dissolutionthe residue was dissolved in ether
  7. customThe ether phase was separated

出典と根拠

ORDレコード
ord-c383f4cca4a8441ba22214930705beff
出典データセット
uspto-grants-2002_03
特許番号
US06352988B2

関連ノート

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