Ethylamine hydrochloride → 6,7-Dimethoxy-2-ethylamino-4-(3-nitrophenyl)quinazoline

反応式

Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([O:23][CH3:24])=[C:7]([O:21][CH3:22])[CH:8]=2)[N:3]=1.Cl.[CH2:26]([NH2:28])[CH3:27]>>[CH3:22][O:21][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[O:23][CH3:24])[N:3]=[C:2]([NH:28][CH2:26][CH3:27])[N:11]=[C:10]2[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=1

参加物

反応物 2

HCID 11198Ethylamine hydrochloride

HCID 121503982-Chloro-6,7-dimethoxy-4-(3-nitrophenyl)quinazoline

生成物 1

HCID 121504026,7-Dimethoxy-2-ethylamino-4-(3-nitrophenyl)quinazoline収率 35.7%

実験手順

Starting from 500 mg 2-chloro-6,7-dimethoxy-4-(3-nitrophenyl)quinazoline and 1.18 g ethylamine hydrochloride, 183 mg of the title compound was obtained as yellow crystals in the same manner as in Production Example 4.

出典と根拠

ORDレコード: ord-25e4fe74ff984ab28f5ed6b958379bdb
出典データセット: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06352989B1

反応ノート

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