1-Bromopropane → 7-Methoxy-3-propyl-2-trifluoromethylbenzimidazole

反応式

[CH3:1][O:2][C:3]1[C:11]2[NH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH2:16](Br)[CH2:17][CH3:18]>>[CH3:1][O:2][C:3]1[C:11]2[N:10]=[C:9]([C:12]([F:15])([F:13])[F:14])[N:8]([CH2:16][CH2:17][CH3:18])[C:7]=2[CH:6]=[CH:5][CH:4]=1

参加物

反応物 2

HCID 78401-Bromopropane

HCID 178488964HCID 178488964、化合物

生成物 1

HCID 183166377-Methoxy-3-propyl-2-trifluoromethylbenzimidazole

実験手順

Prepared from 4-methoxy-2-trifluoromethylbenzimidazole (2.4 g) and propyl bromide (3.02 ml). Purification by flash chromatography on silica eluting with 15% ethyl acetate in hexane gave the title compound as a white solid (2.03 g).

後処理

customPurification by flash chromatography on silica eluting with 15% ethyl acetate in hexane

出典と根拠

ORDレコード: ord-3768b69c0a5644d48eb12c0816af51a4
出典データセット: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06353010B1

反応ノート

読み込み中…

参加物