Ethanol → 1,3-Benzoxazol-4-ol

HRID 275798

反応式

HRID 275798 の反応式
Cl.[NH2:2][C:3]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][C:4]=1[OH:5].O.[CH2:12](O)C>>[OH:10][C:9]1[C:3]2[N:2]=[CH:12][O:5][C:4]=2[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 3

HCID 702EthanolHCID 962WaterHCID 4592471,3-Benzenediol, 2-amino-, hydrochloride (1:1)

生成物 1

HCID 137206971,3-Benzoxazol-4-ol

実験手順

2-Aminoresorcinol hydrochloride (2 g) and triethylchloroformate (4.5 ml) were heated to reflux under nitrogen for 3 h. After cooling to room temperature, the reaction mixture was poured into a mixture of water (70 ml) and ethanol (20 ml). The mixture was stirred vigorously for 30 minutes, then left to stand at room temperature overnight. The beige precipitate which formed was collected by filtration, and dried by azeotroping with toluene to give the title compound as a beige solid (1.2 g).

後処理

  1. temperatureto reflux under nitrogen for 3 h
  2. waitleft
  3. waitto stand at room temperature overnight
  4. customThe beige precipitate which formed
  5. filtrationwas collected by filtration
  6. customdried
  7. customby azeotroping with toluene

出典と根拠

ORDレコード
ord-88646d822d164a579bb5c38570591b6e
出典データセット
uspto-grants-2002_03
特許番号
US06353010B1

関連ノート

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