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Hydrogen iodide → 9-(1-Hydroxy-2-propyl)-6-iodopurine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | 2-(6-Chloropurin-9-yl)propan-1-ol | HCID 454019 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 9-(1-Hydroxy-2-propyl)-6-iodopurine | HCID 23342906 | — |
反応手順
9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%); mp=193°-194°; uv λmax 276 nm (H2O, pH 5.5).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221910 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-a9c0746808a54bc09cad7a9b6fdf2446 |
| 出典メモ | uspto-grants-1980_09 |