N-Methyl-N-methyloxy-2-benzyloxycarbonylamino-5-(3-phenylpropyloxy)benzamide → N-methyl-N-methyloxy-2-amino-5-(3-phenylpropyloxy)benzamide

HRID 275834ノート

反応式

HRID 275834 の反応式
[CH3:1][N:2]([O:32][CH3:33])[C:3](=[O:31])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:6][C:5]=1[NH:20]C(OCC1C=CC=CC=1)=O>C(OCC)(=O)C.CO.[C].[Pd]>[CH3:1][N:2]([O:32][CH3:33])[C:3](=[O:31])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:6][C:5]=1[NH2:20]

参加物

5

反応物 1

HCID 18315368N-Methyl-N-methyloxy-2-benzyloxycarbonylamino-5-(3-phenylpropyloxy)benzamide

生成物 1

HCID 18315339N-methyl-N-methyloxy-2-amino-5-(3-phenylpropyloxy)benzamide

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

N-Methyl-N-methyloxy-2-benzyloxycarbonylamino-5-(3-phenylpropyloxy)benzamide (1.4 g) was dissolved in a mixture of ethyl acetate (10 ml) and methanol (10 ml). To the solution was added 10% palladium-carbon (0.3 g). The mixture was stirred for 24 houks at room temperature under hydrogen atmosphere. The reaction mixture was subjected to filtration. From the filtrate was distilled off the solvent to leave N-methyl-N-methyloxy-2-amino-5-(3-phenylpropyloxy)benzamide as an orange oily product (1.0 g).

後処理

  1. filtrationThe reaction mixture was subjected to filtration
  2. distillationFrom the filtrate was distilled off the solvent

出典と根拠

ORDレコード
ord-cd93fe0adf0b454bb2c8dffa551ad7ba
出典データセット
uspto-grants-2002_03
特許番号
US06352982B1

反応ノート

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