N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide → Benzamide, 2-amino-N,5-dimethoxy-N-methyl-

HRID 275859ノート

反応式

HRID 275859 の反応式
[CH3:1][N:2]([O:24][CH3:25])[C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[NH:12]C(OCC1C=CC=CC=1)=O>C(OCC)(=O)C.CO.[H][H].[C].[Pd]>[CH3:1][N:2]([O:24][CH3:25])[C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[NH2:12]

参加物

6

反応物 1

HCID 18315335N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide

生成物 1

HCID 11514001Benzamide, 2-amino-N,5-dimethoxy-N-methyl-収率 104.2%

試薬・触媒・溶媒 4

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒HCID 178418361HCID 178418361、化合物溶媒

実験手順

In a mixture of ethyl acetate (8 ml) and methanol (10 ml) was dissolved N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide (0.55 g). To the solution was added 10% palladium-carbon (0.1 g). The mixture was stirred for 40 minutes at ordinary temperature under atmospheric pressure in hydrogen streams. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure. From the concentrate, N-methyl-N-methyloxy 2-amino-5-methyloxy-benzamide (0.35 g) was obtained.

後処理

  1. filtrationThe reaction mixture was subjected to filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-3151efb2da3b49d0be0a0571a2d3f433
出典データセット
uspto-grants-2002_03
特許番号
US06352982B1

反応ノート

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