Hydrochloric Acid → HCID 178494701、化合物

HRID 275901ノート

反応式

HRID 275901 の反応式
N[C:2]1[N:7]=[C:6]([OH:8])[C:5]([CH3:9])=[C:4]([CH2:10][O:11][CH3:12])[N:3]=1.Cl.N([O-])=[O:15].[Na+]>O>[OH:15][C:2]1[N:7]=[C:6]([OH:8])[C:5]([CH3:9])=[C:4]([CH2:10][O:11][CH3:12])[N:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 178494689HCID 178494689、化合物

生成物 1

HCID 178494701HCID 178494701、化合物収率 55.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

2-amino-4-hydroxy-6-methoxymethyl-5-methylpyrimidine (2.7 g, 16 mmol) was added to 20% aqueous hydrochloric acid solution (7 ml), and heated to 70° C. A solution of sodium nitrite (2.3 g, 33.3 mmol) in water was added dropwise to a reaction mixture while maintaining the reaction temperature under 70° C. The reaction mixture was cooled to a room temperature. The resulting solid was filtered and dried to give 1.5 g of the titled compound.

後処理

  1. temperaturewhile maintaining the reaction temperature under 70° C
  2. temperatureThe reaction mixture was cooled to a room temperature
  3. filtrationThe resulting solid was filtered
  4. customdried

出典と根拠

ORDレコード
ord-03a96151fb5f478b94ae171dae7024a8
出典データセット
uspto-grants-2002_03
特許番号
US06352993B1

反応ノート

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