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1-Naphthalenemethanamine → 5,6-Dimethyl-2-(1-naphthylmethyl)amino-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Naphthalenemethanamine | HCID 8355 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315743 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5,6-Dimethyl-2-(1-naphthylmethyl)amino-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride | HCID 18315781 | 87.7% |
反応手順
After 1-naphthylmethylamine(0.40 ml, 2.7 mmol) and triethylamine (0.38 ml, 2.7 mmol) were added to a solution of 2-chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(0.5 g, 1.8 mmol) in dimethylformamide, 680 mg of the titled compound was obtained in accordance with the same procedure as in Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06352993B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-543e57fb366240cf863613b557f49a20 |
| 出典メモ | uspto-grants-2002_03 |