2,5-Dimethylaniline → N-(2,5-Dimethylphenyl)acetamide

HRID 275994

反応式

HRID 275994 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH2:4].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CN(C)C1C=CN=CC=1.ClCCl>[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH:4][C:10](=[O:12])[CH3:11]

参加物

5

反応物 2

HCID 72592,5-DimethylanilineHCID 7918Acetic Anhydride

生成物 1

HCID 16304N-(2,5-Dimethylphenyl)acetamide

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 2,5-dimethylaniline (5.30 g) and 4-dimethylaminopyridine (6.41 g) in dichloromethane (90 ml) was added acetic anhydride (4.13 ml) under ice-cooling, and the mixture was stirred for 4 hours. The reaction mixture was washed with 1N hydrochloric acid and a saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate. Removal of the solvent in vacuo gave 2′,5′-dimethylacetanilide (6.09 g).

後処理

  1. temperaturecooling
  2. washThe reaction mixture was washed with 1N hydrochloric acid
  3. dry with materiala saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate
  4. customRemoval of the solvent in vacuo

出典と根拠

ORDレコード
ord-e1d948e4bff14b87b806b0d181e33941
出典データセット
uspto-grants-2002_03
特許番号
US06353025B1

関連ノート

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