化工社化工社 化学情報印刷レポート · 研究参考用
4-Toluenesulfonyl chloride → (1-((4-Methylphenyl)sulfonyl)-1H-imidazol-5-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | Imidazol-4-ylmethanol hydrochloride | HCID 122926 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (1-((4-Methylphenyl)sulfonyl)-1H-imidazol-5-yl)methanol | HCID 382151 | — |
反応手順
To an ice cold solution of 0.08 mole of sodium bicarbonate in 40 ml of water is added 0.02 mole of imidazol-5-ylmethanol hydrochloride followed by a solution of 0.025 mole of tosylchloride in 30 ml of ethyl acetate. The reaction mixture is stirred at room temperature for 5 hours. The organic phase is separated, washed with sodium bicarbonate, and dried over magnesium sulfate and concentrated under reduced pressure. The residue is crystallized from ethyl acetate to afford 1-tosylimidazol-5-ylmethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221914 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-0234d9088d344fc98eb9e0fe5af5aad6 |
| 出典メモ | uspto-grants-1980_09 |