4-Toluenesulfonyl chloride → (1-((4-Methylphenyl)sulfonyl)-1H-imidazol-5-yl)methanol

HRID 27613

反応式

HRID 27613 の反応式
C(=O)(O)[O-].[Na+].Cl.[NH:7]1[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[CH:8]1.[S:14](Cl)([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)(=[O:16])=[O:15]>O.C(OCC)(=O)C>[S:14]([N:7]1[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[CH:8]1)([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)(=[O:16])=[O:15]

参加物

6

反応物 3

HCID 73974-Toluenesulfonyl chlorideHCID 122926Imidazol-4-ylmethanol hydrochlorideHCID 516892Sodium Bicarbonate

生成物 1

HCID 382151(1-((4-Methylphenyl)sulfonyl)-1H-imidazol-5-yl)methanol

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To an ice cold solution of 0.08 mole of sodium bicarbonate in 40 ml of water is added 0.02 mole of imidazol-5-ylmethanol hydrochloride followed by a solution of 0.025 mole of tosylchloride in 30 ml of ethyl acetate. The reaction mixture is stirred at room temperature for 5 hours. The organic phase is separated, washed with sodium bicarbonate, and dried over magnesium sulfate and concentrated under reduced pressure. The residue is crystallized from ethyl acetate to afford 1-tosylimidazol-5-ylmethanol.

後処理

  1. customThe organic phase is separated
  2. washwashed with sodium bicarbonate
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue is crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-0234d9088d344fc98eb9e0fe5af5aad6
出典データセット
uspto-grants-1980_09
特許番号
US04221914

関連ノート

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