Acetone → 5-Chloro-2-(4-methoxyphenoxy)benzenamine

HRID 27623ノート

反応式

HRID 27623 の反応式
COC1C=CC([C:9]2[C:10]([N+]([O-])=O)=[C:11]([O:16][C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[C:19](C4C=CC(OC)=CC=4)[C:18]=3[N+:32]([O-])=O)[CH:12]=[CH:13][C:14]=2Cl)=CC=1.C[C:39](C)=[O:40].S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([O:16][C:11]2[CH:10]=[CH:9][C:14]([O:40][CH3:39])=[CH:13][CH:12]=2)=[C:18]([CH:19]=1)[NH2:32]

参加物

5

反応物 3

HCID 180AcetoneHCID 24489Sodium DithioniteHCID 57238430HCID 57238430、化合物

生成物 1

HCID 24878325-Chloro-2-(4-methoxyphenoxy)benzenamine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

An 80.0 g. portion of the above nitro derivative in 800 ml. of acetone is added to 320.0 g. of sodium hydrosulfite in 800 ml. of water. The mixture is heated to reflux on a steam bath for one hour, cooled and extracted with benzene. The benzene extract is washed with water, dried over anhydrous sodium sulfate, and evaporated in vacuo to a yellow oil. Treatment in hexane, with cooling produces crystals of 5-chloro-2-(p-methoxyphenoxy)-aniline.

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux on a steam bath for one hour
  3. temperaturecooled
  4. extractionextracted with benzene
  5. extractionThe benzene extract
  6. washis washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated in vacuo to a yellow oil
  9. temperatureTreatment in hexane, with cooling

出典と根拠

ORDレコード
ord-88a787f9ffe8471d837f061f01e8337d
出典データセット
uspto-grants-1980_09
特許番号
US04221714

反応ノート

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