関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 1-(Cyclohexylamino)-1-(hydroxymethyl)cyclopentane | HCID 18316142 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt | HCID 69992905 | 195.8% |
反応手順
A 4M HCl solution (p-dioxane, 40 mL) containing 1-(cyclohexylamino)-1-(hydroxymethyl)cyclopentane (Method B4a; 1.9 g, 9.6 mmol) and SOCl2 (0.84 mL, 11.5 mmol) was heated to 70° C. for 18 h. The resulting mixture was cooled to room temp. and concentrated under reduced pressure to yield crude 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt (2.84 g), which was used in the next step without firer purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06353006B1 |
|---|
| 出典データセット | uspto-grants-2002_03 |
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| ORD ID | ord-2c95e3be24164d069c9b63100bdf0900 |
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| 出典メモ | uspto-grants-2002_03 |
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