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6-Chlorothieno[2,3-b]pyridine-2-sulfonyl chloride → HCID 54285997、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Chlorothieno[2,3-b]pyridine-2-sulfonyl chloride | HCID 18176355 | — |
| 反応物 | 3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride | HCID 22870786 | — |
| 生成物 | HCID 54285997 | HCID 54285997 | — |
反応手順
The title compound is prepared from 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 1, Part E using 6-chlorothieno[2,3-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 10% EtOAc/CH2 Cl2 to 25% EtOAc/CH2Cl2 to afford a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731315 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-3fd33ae5f6e6424f853b83bed699d2ad |
| 出典メモ | uspto-grants-1998_03 |