L-Leucinol → HCID 178428753、化合物

HRID 276441

反応式

HRID 276441 の反応式
O[CH2:2][C@@H:3]([NH2:8])[CH2:4][CH:5]([CH3:7])[CH3:6].[CH3:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=1[N:19]=[C:20]=[S:21]>>[CH3:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=1[N:19]=[C:20]1[NH:8][C@@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[CH2:2][S:21]1

参加物

3

反応物 2

HCID 111307L-LeucinolHCID 1456212-Methyl-4-nitrophenyl isothiocyanate

生成物 1

HCID 178428753HCID 178428753、化合物

実験手順

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was converted to (1S)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4S)-2-(2-methyl-4-nitrophenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with 1-bromo-2-ethylbutane according to Method D2a to afford (4S)-2-(2-methyl-4-nitrophenylimino)-4-isobutyl-3-(2-ethyl-1-butyl)-1,3-thiazolidine HCl salt.

出典と根拠

ORDレコード
ord-9b9b4a47d5024dd186f1bf36b3a6497c
出典データセット
uspto-grants-2002_03
特許番号
US06353006B1

関連ノート

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