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Thionyl Chloride → (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | L-Leucinol | HCID 111307 | — |
| 反応物 | 2-Ethyl-4-cyanophenyl isothiocyanate | HCID 18316102 | — |
| 生成物 | (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine | HCID 178436590 | — |
反応手順
(1S)-1-(Hydroxymethyl)-3-methylbutylamine was reacted with SOCl2 followed by 4-cyano-2-ethylphenyl isothiocyanate according to Method C2a to give (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-cyano-2-ethylphenylimino)-3,4-diisobutyl-1,3-thiazolidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-729bc953ecec46e080796b4cb27e7f59 |
| 出典メモ | uspto-grants-2002_03 |