化工社化工社 化学情報印刷レポート · 研究参考用
Ethanolamine → (4S)-2-(2-methyl-4-nitrophenylimino)-3,4-diisobutyl-1,3-thiazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | Isobutylaminehydrochloride | HCID 21133 | — |
| 反応物 | (+)-L-Leucine methyl ester | HCID 65105 | — |
| 反応物 | L-Leucinol | HCID 111307 | — |
| 反応物 | 2-Methyl-4-nitrophenyl isothiocyanate | HCID 145621 | — |
| 反応物 | (2S)-4-methyl-2-(isobutylamino)pentanol | HCID 22951222 | — |
| 生成物 | (4S)-2-(2-methyl-4-nitrophenylimino)-3,4-diisobutyl-1,3-thiazolidine | HCID 10291492 | — |
反応手順
(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (2S)-4-methyl-2-(isobutylamino)pentan-1-ol as described in Method B4c. The resulting 2-hydroxyethylamine was converted to N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride according to Method B7c. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride to Method C1b to afford (4S)-2-(2-methyl-4-nitrophenylimino)-3,4-diisobutyl-1,3-thiazolidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-70e26867b02c4090acfc1fa3aedbbcdd |
| 出典メモ | uspto-grants-2002_03 |