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Ethanolamine → HCID 178445848、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | 4-Nitro-1-naphthylamine | HCID 13057 | — |
| 反応物 | L-Isoleucine, methyl ester | HCID 75735 | — |
| 反応物 | (2S)-2-amino-3-methylpentan-1-ol | HCID 11789185 | — |
| 反応物 | 4-Nitro-1-naphthyl isothiocyanate | HCID 18316079 | — |
| 生成物 | HCID 178445848 | HCID 178445848 | — |
反応手順
(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Nitro-1-naphthylamine was converted to 4-nitro-1-naphthyl isothiocyanate according to Method A2b. 4-Nitro-1-naphthyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride to Method C1a to give (4S)-2-(4-nitro-1-naphthylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-nitro-1-naphthylimino)-4-butyl-3-isobutyl-1,3-thiazolidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-44b8242f55f74fb0b14e66dcd94b14b7 |
| 出典メモ | uspto-grants-2002_03 |