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2-Amino-2-phenylethan-1-ol → HCID 178428749、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-2-phenylethan-1-ol | HCID 134797 | — |
| 反応物 | 2-Methyl-4-nitrophenyl isothiocyanate | HCID 145621 | — |
| 反応物 | (1S)-2-chloro-1-benzylethylammonium chloride | HCID 69994545 | — |
| 反応物 | (1S)-2-chloro-1-phenylethylammonium chloride | HCID 86590174 | — |
| 生成物 | HCID 178428749 | HCID 178428749 | — |
反応手順
(1S)-1-Phenyl-2-hydroxyethylamine was converted to (1S)-2-chloro-1-phenylethylammonium chloride according to Method B7b. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S)-2-chloro-1-benzylethylammonium chloride according to Method C1a to give (4S)-2-(2-methyl-4-nitrophenylimino)-4-phenyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(2-methyl-4-nitrophenylimino)-4-phenyl-3-isobutyl-1,3-thiazolidine HCl salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-93849a706e05443aa0791ed8924f104a |
| 出典メモ | uspto-grants-2002_03 |