1-Bromo-2-methylpropane → 2-(2-Methyl-4-nitrophenylimino)-3-isobutyl-4,4-dimethyl-1,3-thiazolidine
反応式
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[NH:16][C:15]([CH3:18])([CH3:17])[CH2:14][S:13]1.[CH2:19](Br)[CH:20]([CH3:22])[CH3:21]>>[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[N:16]([CH2:19][CH:20]([CH3:22])[CH3:21])[C:15]([CH3:18])([CH3:17])[CH2:14][S:13]1参加物
3
実験手順
Methyl aminoisobutyric acid was converted to methyl aminoisobutyrate HCl salt according to method B1c, Step 1. The ester was reduced to 3-hydroxy-2-methyl-2-propylamine according to Method B1c, Step 2. The 2-hydroxyethylamine was treated with SOCl2 according to Method B7b, followed by 2-methyl-3-nitrophenyl isothiocyanate according to Method C1a to give 2-(2-methyl-4-nitrophenylimino)-4,4-dimethyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford 2-(2-methyl-4-nitrophenylimino)-4,4-dimethyl-3-isobutyl-1,3-thiazolidine.
出典と根拠
- ORDレコード
- ord-acda71eb5e0a4cf6a3c5a96b7212bd7b
- 出典データセット
- uspto-grants-2002_03