化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 4-Aminophenol | HCID 403 | — |
| 反応物 | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide | HCID 352935 | 73% |
反応手順
A mixture of 4-aminophenol (27 g, 0.25 mole) and 4-nitrobenzenesulfonyl chloride (55 g, 0.25 mole) in pyridine (500 ml) was heated under reflux for 4 hours. The reaction mixture was poured in ice water and acidified with acetic acid. The crude product weighed 86 g. Recrystallization from CH3NO2 provided 53 g (73%) of material used in Part B; m.p. 197°-198°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04222948 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-74de4695fe0f4d1bb565c214767e9a0f |
| 出典メモ | uspto-grants-1980_09 |