化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 4-[[(4-Nitrophenyl)sulfonyl]amino]-3-methylphenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| 反応物 | 4-Amino-m-cresol | HCID 17819 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 4-[[(4-Nitrophenyl)sulfonyl]amino]-3-methylphenol | HCID 23341651 | 84.3% |
反応手順
To a stirred mixture of 4-amino-3-methylphenol (24 g, 0.2 mole) in 600 ml of pyridine was added all at once p-nitrobenzenesulfonyl chloride (Eastman) (45 g, 0.2 mole) followed by heating on a steam bath for 2 hours. The dark oily solution was poured into 4 liters of water and then treated with glacial acetic acid until acid. The tar crystallized on standing to give after filtration 67 g (100%) of brown solid. The entire sample was recrystallized from CH3NO2 to give 52 g of pure intermediate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04222948 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-6f7d5deaa49f4f3980efc0c7edca883c |
| 出典メモ | uspto-grants-1980_09 |