化工社化工社 化学情報印刷レポート · 研究参考用
1-Bromo-2-methylpropane → 1-Isobutyl-2-(4-cyanophenylimino)-3-thia-1-azaspiro[4.4]nonane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-2-methylpropane | HCID 6555 | — |
| 反応物 | 2-(4-Cyanophenylimino)-3-thia-1-azaspiro[4.4]nonane | HCID 178510030 | — |
| 生成物 | 1-Isobutyl-2-(4-cyanophenylimino)-3-thia-1-azaspiro[4.4]nonane | HCID 18316065 | — |
反応手順
1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7e to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. The 2-chloroethylamine was reacted with 4-cyanophenyl isothiocyanate according to Method C1a to give 2-(4-cyanophenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford 1-isobutyl-2-(4-cyanophenylimino)-3-thia-1-azaspiro[4.4]nonane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-1f272ec2604c411eb843d11861894a38 |
| 出典メモ | uspto-grants-2002_03 |