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Ethanolamine → 1-Aminocyclopentanemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 4-Cyano-2-methylphenyl isothiocyanate | HCID 18316299 | — |
| 生成物 | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| 生成物 | 4-Amino-3-methylbenzonitrile | HCID 7010316 | — |
| 生成物 | 1-(Chloromethyl)cyclopentan-1-amine hydrochloride | HCID 69992485 | — |
反応手順
4-Cyano-2-methylaniline was synthesized as described in Method A1a. The aniline was converted to 4-cyano-2-methylphenyl isothiocyanate according to Method A2a, Step 3. 1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7a to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. The 2-chloroethylamine was reacted with 4-cyano-2-methylphenyl isothiocyanate according to Method C1a to give 2-(4-cyano-2-methylphenylimino)-1-thia-3-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2b to give 3-isobutyl-2-(4-iodo-2-methylphenylimino)-1-thia-3-azaspiro[4.4]nonane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-e7c9bdddc8d9475398950b9579b3c4e2 |
| 出典メモ | uspto-grants-2002_03 |