4-Amino-1-naphthalenecarbonitrile → HCID 178510033、化合物

HRID 276576

反応式

HRID 276576 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]#[N:13])=[CH:4][CH:3]=1.C(C1[C:25]2[C:20](=C[CH:22]=[CH:23][CH:24]=2)[C:19]([N:26]=[C:27]=[S:28])=CC=1)#N.Cl.NC1(CCl)CCCC1>>[C:12]([C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([N:1]=[C:27]2[NH:26][CH2:19][C:20]3([CH2:25][CH2:24][CH2:23][CH2:22]3)[S:28]2)=[CH:3][CH:4]=1)#[N:13]

参加物

4

反応物 3

HCID 428284-Amino-1-naphthalenecarbonitrileHCID 183160684-Isothiocyanato-1-naphthonitrile2 回HCID 699924851-(Chloromethyl)cyclopentan-1-amine hydrochloride

生成物 1

HCID 178510033HCID 178510033、化合物

実験手順

1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7a to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. 1-Amino-4-cyanonaphthalene was converted into 4-cyano-1-naphthyl isothiocyanate according to Method A2a, Step 3. The 2-chloroethylamine was reacted with 4-cyano-1-naphthyl isothiocyanate to Method C1a to give 2-(4-cyano-1-naphthylimino)-1-thia-3-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2b to give 3-isobutyl-2-(4-cyano-1-naphthylimino)-1-thia-3-azaspiro[4.4]nonane.

出典と根拠

ORDレコード
ord-eaf32b88be5447f78b5e8b51e477263a
出典データセット
uspto-grants-2002_03
特許番号
US06353006B1

関連ノート

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