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Ethanolamine → 1-Aminocyclopentanemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | 2-Aminothiophene | HCID 97373 | — |
| 反応物 | 5-Nitrothiophene-2-carbonitrile | HCID 519294 | — |
| 反応物 | 5-Aminothiophene-2-carbonitrile | HCID 14531140 | — |
| 反応物 | 1-(Chloromethyl)cyclopentan-1-amine hydrochloride | HCID 69992485 | — |
| 生成物 | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| 生成物 | HCID 178510031 | HCID 178510031 | — |
反応手順
2-Cyano-5-nitrothiophene was reduced to 2-amino-5-cyanothiophene according to Method A1a. The aminothiophene was converted to 5-cyano-1-thiophene isothiocyanate according to Method A2b. 1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was converted to 1-chloromethylcyclopentanamine HCl salt according to Method B7e. 1-Chloromethylcyclopentanamine HCl salt was reacted with 5-cyano-1-thiophene isothiocyanate according to Method C1e to give 2-(5-cyanothienylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give 2-(5-cyanothienylimino)-1-isobutyl-3-thia-1-azaspiro[4.4]nonane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-8da896f4d1a14f5aaf0687f0f3e58c25 |
| 出典メモ | uspto-grants-2002_03 |