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Ethanolamine → 1-Aminocyclopentanemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Methyl 4-amino-3-methylbenzoate | HCID 2736799 | — |
| 反応物 | Methyl 4-isothiocyanato-3-methylbenzoate | HCID 18316033 | — |
| 生成物 | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| 生成物 | HCID 178498120 | HCID 178498120 | — |
反応手順
Methyl 4-amino-3-methylbenzoate was converted to 4-methoxycarbonyl-2-methylphenyl isothiocyanate according to Method A2b. 1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was sequentially reacted with SOCl2 and 4-methoxycarbonyl-2-methylphenyl isothiocyanate according to Method C2a to give 2-(4-methoxycarbonyl-2-methylphenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method D2h to give 2-(4-methoxycarbonyl-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-ab93818b37e34ab69d7d23b2c97ac994 |
| 出典メモ | uspto-grants-2002_03 |